EFFECTS OF FAC CHEMOTHERAPY ON ANTI MULLERIAN HORMONE IN PREMENOPAUSAL BREAST CARCINOMA

Abstrak: Breast cancer is the most common carcinoma in women world. Anti-Mullerian Hormone (AMH) a hormone secreted by primary, secondary, and small antral ovarian follicles of <4mm. The chemotherapy regimen toxic to 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). In Indonesia, there had been no study on effect FAC AMH premenopausal breast patients. This aims determine employed prospective cohort design. Inclusion criteria were carcinoma, premenopausal, history (-). Exclusion surgery, pelvic radiation, GnRH-agonist therapy, smoking for ≥10 years, obesity, dropout. Subjects examined before 1st after 4th chemotherapy. Statistical test was done with Wilcoxon test, significant if p≤0.05. average level 1.51±1.957; 0.24±0.587. result comparing levels p<0.0001. reduces patients carcinoma.Keywords: chemotherapy, AMH.